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Alegre
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Joined: 23 Jul 2007
Posts: 255
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| Abstract: Ovarian Cysts and Reduced Risk of Breast Cancer? |
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http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17616808&ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Breast Cancer Res Treat. 2007 Jul 7
$$ Buy full article: http://www.springerlink.com/content/n82kx4t31n306822/
Ovarian cysts and breast cancer: results from the Women's Contraceptive and Reproductive Experiences Study.
Knight JA, Lesosky M, Blackmore KM, Voigt LF, Holt VL, Bernstein L, Marchbanks PA, Burkman RT, Daling JR, Whittemore AS.
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Box 18, Toronto, ON, Canada, M5T 3L9, knight@mshri.on.ca.
A diagnosis of ovarian cysts is likely an indicator of hormonal milieu and thus may be related to breast cancer risk. Recent studies have reported an inverse relationship between prior ovarian cyst diagnosis and breast cancer risk. We evaluated this relationship in the Women's Contraceptive and Reproductive Experiences (CARE) Study, a population-based case-control study conducted in Atlanta, Detroit, Philadelphia, Los Angeles, and Seattle.
Cases had first primary invasive breast cancer diagnosed between 1994 and 1998 at ages 35-64 years. African American women were over-sampled. Controls were identified through random digit dialling and were frequency matched to cases on centre, race, and five-year age group. A total of 4575 cases and 4682 controls were interviewed. We used unconditional logistic regression adjusted for age and study centre within racial groups to estimate the odds ratio (OR) and 95% confidence interval (CI) for the relationship between prior ovarian cysts and breast cancer.
Ovarian cyst diagnosis was associated with a significantly reduced risk among Caucasians (OR = 0.85, 95% CI 0.76-0.96) and among African Americans (OR = 0.68, 95% CI 0.57-0.81)
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The association in Caucasians was not significant within subgroups defined by menopausal status, hormone use, or gynecological surgery while the OR estimates in African Americans were consistently lower and frequently significant
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These data are consistent with the previously reported
inverse association between ovarian cysts and breast cancer
, but the evidence for a relationship was
stronger in African Americans than Caucasians
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Additional studies are required to determine the specific cyst type(s) responsible for the observed relationship.
PMID: 17616808 [PubMed - as supplied by publisher] |
Tue Jul 24, 2007 10:12 am |
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Alegre
Regent Member
Joined: 23 Jul 2007
Posts: 255
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| Another Related Article |
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Ovarian cysts linked to lower breast cancer risk
What breastcancer.org says about this article:
Benign (not cancerous) ovarian cysts are fairly common. Some women with ovarian cysts also have problems with infertility and irregular menstrual cycles, which suggests that ovarian cysts may be associated with abnormal hormone levels. Because of this, some researchers thought that ovarian cysts might be associated with a higher risk of breast cancer.
This study found that the risk of breast cancer was lower in women with a history of ovarian cysts. The reason for this lower risk isn't clear. More research needs to be done on the relationship between ovarian cysts and breast cancer risk. But the results are good news if you've been diagnosed with benign ovarian cysts.
Learn more about breast cancer risk in our Lower Your Risk section.
Last Updated: 2006-10-13 16:41:48 -0400 (Reuters Health)
NEW YORK (Reuters Health) - Ovarian cysts do not increase the risk of breast cancer, according to the results of a review study. In fact, such cysts were associated with a 30-percent decreased risk of breast cancer, the investigators report.
Non-cancerous or "benign" ovarian cysts are associated with infertility and menstrual cycle irregularities, Dr. Cristina Bosetti and colleagues explain in their report, published in the International Journal of Cancer. On that basis, it has been suggested that ovarian cysts may alter hormone levels that in turn could influence breast cancer risk.
Individual studies have failed to either support or refute that theory. Therefore, Bosetti, from Instituto di Ricerche Farmarmacologiche Mario Negri in Milan, Italy, and her team combined data from two hospital-based studies conducted in Italy between 1983 and 1991 and between 1991 and 2001, as well as one performed between 1992 and 2001 in Switzerland.
The researchers included in their analysis 6315 breast cancer patients and 6315 comparison subjects admitted to the same hospitals for unrelated reasons. The subjects had been interviewed while hospitalized regarding demographic, menstrual and reproductive factors, including a history of ovarian cysts.
Five percent of breast cancer patients and 7 percent of comparison subjects reported a history of ovarian cysts, Bosetti and her associates report. This translates into a 28 percent reduced risk of breast cancer in subjects with ovarian cysts.
The association between ovarian cysts and reduced breast cancer risk was strongest among women with irregular menstrual cycles, those who had never used oral contraceptives, those who undergone ovary removal or hysterectomy, and those with lower body weights.
These findings prompted the investigators' to conclude that "although some hormonal correlates of ovarian cysts may have a role on breast cancer risk, a biological explanation of this association is still unclear."
SOURCE: International Journal of Cancer, October 2006.
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Alegre |
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Tue Dec 11, 2007 4:12 pm |
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